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Changes in mitochondrial RNA production in cells treated with nucleoside analogues

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Concomitantly, selective degeneration of nigrostriatal dopaminergic neurons results in severe dopamine depletion within the basal ganglia circuitry [12, 13]

In this regard, it has been proposed that a viral infection in which selfantigens that generate molecular mimicry with myelin proteins cause a loss of tolerance against it, which results in the destruction of myelin mediated by activated T lymphocytes in white matter of the brain and sometimes extending into the gray matter, resulting in defects in the conduction of nerve impulses that leads to symptoms, depending on the affected site of the brain or spinal cord [1] (Figure 1)

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