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Independent of increased delivery alone, these next-generation nanoparticles are more frequently multifunctional, where their surface can be functionalized while also entrapping therapeutics inside the nanoparticle, so generating more creative approaches in actively targeting tumor sites and eliciting biological effects with therapeutic usefulness (8)

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Clinical follow-up into puberty and adulthood is reported for only two patients: P2 in this study and one patient reported by Reardon and colleagues

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