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Carey, E

Atherosclerosis, inflammation and the accumulation of lipids in the inner layer of blood vessel walls lead to vascular blockage and contributes to the development of coronary heart disease, cerebrovascular disease and peripheral arterial vascular disease, and is associated with significant clinical morbidity and mortality rates (57)

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The results are similar in quality to that of the training set despite the considerable size and complexity of many of these mols., demonstrating the ability of the method to accurately handle substituent effects without explicit parametrization thereof