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Kadia TM, Cortes JE, Borthakur G, Garcia-Manero G, Jabbour E, Ferrajoli A, Verstovsek S, Ravandi F, Pemmaraju N , Daver NG, Konopleva M, Wang X, Kantarjian HM

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Indeed, combining TMAO with immune checkpoint blockade therapy, such as anti-PD1 and anti-TIM3 antibodies, further reduced tumor burden and improved survival compared to monotherapies alone