glutathione s transferase oxidative stress Overexpression of S-Transferases in Human Diseases: Drug Targets and Therapeutic Implications Glutathione S-transferase polymorphisms: cancer incidence

Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

Ngi ta pht hin hm lng vitamin C thp c th lin quan n tnh trng sa st tr tu v mt tr nh ngi cao tui

It is the most abundant amino acid in the blood and in the muscles, where it accounts for about 60% of the free amino acid pool

doi: 10.4103/jomfp.jomfp_169_25 103 BridgeGRashidSMartinSA

However these studies are small in number as well as in sample sizes