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Moreover, G6PD and transketolase inhibitors, targeting PPP, were verified to induce ROS-mediated apoptosis in TC cells [94]

Personalization informed by metabolic profiling, genomic insights, and biomarker monitoring may further optimize dietary response, allowing clinicians to adjust macronutrient ratios and caloric targets based on individual tolerance and treatment stage

Model analysis Selection of parameters for estimation The methodology to select parameters for estimation involves first conducting local sensitivity analysis (LSA) to obtain a set of important parameters, and then determining from this set of parameters which are identifiable, that is for which parameters a value can be identified from the data, taking into account the model structure

Protects the body from free radicals that cause oxidative stress

In these disorders, neurological impairments can manifest soon after birth