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These include 1) congenital pernicious anaemia, where there is a genetic defect in IF synthesis, leading to B12 malabsorption, 2) Imerslund-Grsbeck Syndrome (IGS) caused by mutations in genes encoding cubulin and amnionless , 3) inherited HC or TCII deficiencies, and 4) intracellular cobalamin defects (CblA-CblG defects)

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In the BPC 157 rats in the 2nd week, compared to the controls (Figure 19 and Figure 20), a moderate synthesis of collagen type 1 fibers was visualized using polarized microscopy Sirius red staining (Figure 20)

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