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AOD-9604 has Phase I through Phase III human PK, safety, and tolerability data plus FDA GRAS status granted in 2014

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Often without accounting for bioavailability differences between intraperitoneal (animal studies) and subcutaneous (human application) routes

Researchers across the USA, UK, Australia, Canada, and Germany have shown growing interest in NNMT inhibition as a novel approach to metabolic research, distinct from traditional pathways targeted by GLP-1 compounds and other weight-related research molecules

On day 12, mice were subjected to a 4 h fast period, then deeply anesthetized using isoflurane and trunk blood was collected by decapitation