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At the same time, the combination of metformin with other chemotherapy agents or radiotherapy may enhance its anti-tumor effect and provide more options for glioma treatment

108 In another study, Kaur et al developed a nanoemulsion to improve the nose-to-brain delivery of memantine which had a particle size of ~11 nm, PDI of 0.080, and ZP of 19.6 mV

A boxplot was created using ggplot2 (v3.5.1)

As a noteworthy factor whose activity seen to correlate with depression in the cerebral cortex, xanthine oxidase was also inhibited by Lactobacillus paracasei CCFM1229 and Lactobacillus rhamnosus CCFM1228, which also became an essential link between Lactobacillus intervention in depression [89] Expectedly, there also existed researches attributing the protective effect of Lactobacillus to its product such as ergothioneine produced by Lactobacillus reuteri

finally, Ibrahim et al