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For instance, 25-hydroxycholesterol suppresses CYP51A1 mRNA levels in both human adrenocortical H295R and hepatocellular carcinoma HepG2 cells under cholesterol-deprived conditions [17]

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404 Furthermore, NNMT depletion elevates the NAD(H) + levels that result in an enhanced expression of sirtuin target genes and a reduced H3K9Ac