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5-Amino-1MQ has been investigated in preclinical models as a selective inhibitor of NNMT, an enzyme that catalyses the methylation of nicotinamide and has been referenced in the literature in connection with cellular energy metabolism, NAD + -associated signalling pathways, and energy homeostasis

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Because the deacetylase activity of sirtuins is strictly NAD + -dependent 30 , we examined the impact of CD38 inhibition on sirtuin function