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Excitotoxic neurodegeneration is associated with a focal decrease in metabotropic glutamate receptor type 5 availability: an in vivo PET imaging study

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In the in vivo studies, adult Wistar rats were divided into five groups and 3nitro propionic acid (3NPA) (10 mg/kg/day, i.p .), 3NPA alone and with arbutin (50 and 100 mg/kg/day, p.o .) was administered for 21 days