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The energy boost from B12 is often the first noticeable change, with many patients reporting improved alertness and reduced fatigue within the first few days after their initial injection

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Furthermore, exposure of human brain endothelial cells to 10% serum from recovered individuals and individuals with long COVID resulted in the upregulation of ICAM1 , VCAM1 and TNF transcripts compared to sera from unaffected individuals (Extended Data Fig