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Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

In addition, cystine-glutamate antiporter (system Xc-)/GPX4 is important in ferroptosis: pharmacological inactivation of system Xc- or GPX4 can induce ferroptosis, suggesting the crucial roles of the glutathione-dependent antioxidant defenses in preventing ferroptosis [16, 17, 21, 22]

In addition, NADPH oxidase (NOX) family, which is able to decrease the available level of intracellular NADPH, was found to be upregulated in several RAS mutant tumors ( KRAS mutant Calu-1 non-small cell lung cancer cells ( Thioredoxin, a member of cellular antioxidant family (Nordberg and Arner, 2001), plays an important role in suppressing ferroptosis by maintaining and regulating the redox homeostasis

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Interaction with other non-enzymatic antioxidants While GSH is the most important small molecular weight antioxidant produced in the cells, there are other small molecular antioxidants obtained from the diet such as vitamins E (-tocopherol) and C (ascorbic acid)
