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For instance, drug exposure drives the phenotypic alterations of tumor cells, including dedifferentiation, EMT or trans-differentiation, marked by upregulated EMT-related transcriptional factors (TFs), including Zinc finger E-box binding homeobox 1 (ZEB1), ZEB2 and SLUG, that suppress pro-apoptotic proteins (BIM, BMF) and activate anti-apoptotic proteins (Bcl-xL, BCL- 2, MCL1) [38,39,40]
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doi: 10.2337/diabetes.51.1.174
Indeed, KB are able to change GABA and glutamate aminoacid metabolism thereby inhibiting glutamatergic excitatory transmission and mitigate neuronal hyperexcitability (73)
That's because B12 binds to protein and, as the body ages, stomach acid decreases
