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Specifically, it has been evidenced that berberine impairs the formation of the PPAR-NF-B transcriptional complex, downregulates CREB and EGR-1 expressions, and consequently suppresses cellular proliferation and inflammatory responses ( Illicium verum is a medicinal and edible resource that have been proven to possess anti-inflammatory properties

Stress-response, cytoprotection, and DNA-damage signaling Phosphoinositide 3-Kinase-Protein Kinase B/Mechanistic Target of Rapamycin (PI3K-AKT/mTOR) Pathway The PI3K-AKT pathway integrates trophic and stress signals following irradiation

This effect was similarly observed in rats with doses of 7.530 mg/kg (i.p.) (Shen et al

In: Berkowitz AL, eds

2004 Aug;113(8):672-5