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In human beings, this substance is widely distributed in the various organs and tissues, with the maximum concentration in the liver, followed by the spleen and kidneys

KD ameliorated UC-induced intestinal barrier damage by inhibiting the overactivation of the PI3K/Akt/NF-B signaling pathway, attenuating the inflammatory response, including restoration of the intestinal villi and mitochondrial structure, and modulating the gut microbiota (increasing Alloprevotella , Treponema , Prevotella and Prevotellaceae , and decreasing Escherichia_Shigella and Desulfovibrio ) to optimize further the intestinal microenvironment (Liu et al., 2020)

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doi: 10.1016/S0885-5765(03)00075-4 45 LoveA

The core processes facilitating wound repair were linked to lipid peroxidation and the release of cytochrome c, which in turn activated caspase pathways