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Available evidence suggests that ferroptosis integrates multiple upstream damage signals, including pathogenic bacterial infection, iron overload, and oxidative stress, and may exacerbate tissue destruction and inflammation amplification through positive feedback loops
Furthermore, cellular senescence and the SASP exacerbate chronic inflammation and glial dysfunction, with sex differences and lipid metabolism playing modulating roles
Chronic drinkers are at risk of developing alcoholic neuropathy and other nerve-related issues
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Pharmacol Ther 225:107846
