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Specifically, one study found that when leaky Madin-Darby canine kidney type II cells were treated with LA, tight junction proteins, including occludin and claudin-3, had less intracellular distribution (and concurrently more membrane expression), whereas actin was more associated with intercellular junctions (25)
It follows that diabetes-related neuroinflammation exacerbates neurodegenerative disease and is an important regulatory mechanism for cognitive dysfunction
88% had an ECOG PS of 0 or 1
