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Figure 1 Degradation of iron regulatory protein Excessive ferrous iron can promote the generation of reactive oxygen species (ROS) through Fenton reaction, thus causing toxic effects on cells (20)

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doi:10.1016/j.enzmictec.2007.10.008 Liang G, Du G, Chen J (2008b) Enhanced glutathione production by using low-pH stress coupled with cysteine addition in the treatment of high cell density culture of Candida utilis