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KPV: The Anti-Inflammatory Powerhouse What it is: KPV is a naturally occurring peptide fragment with potent anti-inflammatory effects

doi: 10.1007/s10529-011-0592-x

Dysregulated expression of astrocytic functional proteins, such as glutamate transporter-1 (GLT-1), aquaporin-4 (AQP4), and glutamine synthetase (GS), not only exacerbates mood disorders but also influences seizure thresholds ( activates the Mitogen-Activated Protein Kinase (MAPK) pathway to enhance serotonin transporter (SERT) activity, leading to decreased synaptic 5-HT concentrations and thereby further inducing depressive-like behaviors (Zhu et al., 2010)

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