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and extended their own studies on cell age dependent hemichrome binding to band 3 protein (Waugh and Low, 1985) by asking whether the clustering of band 3, which is induced by denatured hemoglobin might also promote binding of autologous IgG (Low et al., 1985)

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For instance, if nutritional deficiencies are the cause of Beau's lines, your doctor may advise dietary changes or supplements to address the issue