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These changes were characterized by either an increase in muscle size and density or a reduction in fat content

Although clinical trials specifically for MASH have not yet been conducted, preclinical studies confirm significant regulatory effects on hepatic metabolism, providing a novel strategy for targeted MASH therapy and supporting future translational research

Whether this produces beneficial or detrimental effects depends on individual methylation pathway capacity, genetic polymorphisms (like MTHFR variants), and baseline homocysteine levels