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690 Bioinformatics analysis and qPCR results of rat spinal cord tissue showed that mRNA levels of PTGS2, JUN, RELA, ATF3, TLR4, HMOX1, and STAT3 were upregulated, while mRNA levels of MAPK9, MAPK1, and VEGFA were downregulated

196 When the Wnt/-catenin pathway is activated, it can reduce lipid ROS production in gastric cancer cells, and the -catenin/TCF4 transcription complex can directly bind to the GPX4 promoter region, enhancing its expression and thereby inhibiting cell ferroptosis

Researchers continue exploring its role in circadian rhythm activity, sleep regulation mechanisms, and neuropeptide interactions, making it one of the most recognized peptides within sleep-focused research categories.

*Correspondence: Lidiia Mys, [email protected] This article was submitted to Mitochondrial Research, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Nat Cell Biol 17:759770