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The enhanced cocktails, CILy (CHIR+IDE1+Ly) and CIP (CHIR+IDE1+PD), significantly increased the expression of DE markers SOX17 and FOXA2, with CIP showing the highest efficiency, comparable to the traditional CA method

As shown in Figure 4, GHK-Cu significantly inhibited the LPS-induced phosphorylation of p38 MAPK and slightly decreased phosphorylation of JNK1/2 whereas the phosphorylation of ERK1/2 was not affected

Uncontrolled hypertension exacerbates CKD progression through nephron loss, sympathetic activation, and endothelial dysfunction [2, 3]

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Ratajczak et al