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PMID 11994745

Beyond thyroidal hyperfunction, Graves disease may manifest with extra-thyroidal complications, most notably thyroid-associated orbitopathy, in which fibroblasts and preadipocytes in the orbit express the TSHR and insulin-like growth factor 1 receptor (IGF-1R), leading to tissue expansion, edema, and fibrosis under autoantibody stimulation [19,20]

[TIP] If the in-solution digestion is chosen (rather than precipitation), dilute the urea concentration to less than 2 mol/L

"First shipments of PfizerBioNTech vaccine in Singapore by end-Dec

- Speak with a provider first: Dont stop or change your dose without guidance