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Recently, studies have shown that APR-246 can exert additional effects, particularly through antagonizing the glutathione (GSH) and thioredoxin reductase system 4,5 , leading to increased reactive oxygen species (ROS)

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Regulating immunity and intestinal function Mediating the interaction between oxidative stress and inflammatory response is one of the key mechanisms for MSM to regulate immune response [5,6]

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Statistical analysis The GraphPad Prism 6.0 software was used for the statistical analysis (GraphPad Software, Inc., San Diego, CA)