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Transparent communication between patients and providers is essential

People with ADHD may struggle with task initiation (getting started on activities), task persistence (sticking with activities until completion), and cognitive flexibility (adapting to changing rules or situations)

Though most PD cases are now believed to be idiopathic, 1020% of patients suffer from Mendelian inheritance-based monogenic PD

Orally or even by injection, most short peptides face a gauntlet: peptidases in blood and tissue that chop them within minutes, poor membrane permeability that keeps them out of cells, and for any DNA-level mechanism the further barrier of reaching the nucleus intact

doi: 10.1126/science.abd0811 65 BrueyJMBruey-SedanoNLucianoFZhaiDBalpaiRXuCet al