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The median duration of postinjection catheterization for these patients treated with BOTOX 200 Units (n = 33) was 289 days (minimum 1 day to maximum 530 days), as compared to a median duration of 358 days (minimum 2 days to maximum 379 days) for patients receiving placebo (n = 7)

This suggests that CMA knockout and overactivation may differentially regulate ferroptosis, necessitating tight control of CMA expression

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2.1.3 Immune pathways Immune signaling is another crucial component of gut-brain communication (Kasarello et al., 2023)