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In humans, direct ANP infusion at maximal dose increases lipolysis greater than 10-fold (114) and can decreases blood pressure, and increases post-prandial lipid oxidation and energy expenditure (111), suggesting therapeutic benefits of ANP treatment are possible in man

Evidence revealed that endogenous and exogenous IGF-1 administration protects against the onset and progression of diabetic cardiomyopathy [278, 279]