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Some senolytics, such as FOXO4-DRI, require peptide-based delivery, which is complex and may limit clinical application.58 Blood-brain barrier penetration is another challenge, making it difficult for senolytics to target neurodegenerative diseases effectively.121 Long-Term Consequences and Need for Repeated Treatment: The long-term effects of senolytic therapy remain unclear, as eliminating senescent cells could disrupt tissue homeostasis

doi: 10.1111/bph.14848

Greco, V., Lanza, V., Tomasello, B., Naletova, I., Cairns, W

While these processes support their proposed healing advantages, they are also involved in tumour growth

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