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Furthermore, treatment of rat hippocampal cells and SHSY5Y human neuroblastoma cells with H 2 O 2 at the early stages of oxidative stress exposure results in tau dephosphorylation at the tau1 epitope by CDK5 via Pin1 activation (203)

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Diagnosis Definitive diagnosis should be based on a characteristic history and clinical signs and laboratory test results that rule out other disorders associated with non-inflammatory alopecia such as, hypothyroidism, sex hormone imbalance in intact dogs, hyperadrenocorticism, follicular dysplasia, and flank alopecia

However, the majority of existing studies have focused on male sexual dysfunction, with significantly less research dedicated to exploring its efficacy in FSD