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The test was two sided at the 0.05 significance level, and effect size (for the A-dopamine versus oral l-dopa alone treatment) was estimated using Hedges g for paired data and calculated using rank-transformed values 32

Despite the use of rodents and small mammals being commonplace in research, in particular for the development of novel therapeutic agents, caution still needs to be practiced when extrapolating research data to clinical applications

This may increase inflammation and bacterial activity