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Systemic carnitine deficiency (OCTN2 Abnormality), In: The Japanese Society for Inherited Metabolic Diseases ed

found that SIAH1, an E3 ubiquitin protein ligase, ubiquitinates HMGCR and influences cholesterol metabolism by regulating key enzymes in cholesterol synthesis, thereby reducing sensitivity to the drug cisplatin ( 4.5 Fatty acid oxidation FAO utilizes acetyl-CoA subunits generated from fatty acids to produce nicotinamide adenine dinucleotide (NADH), acetyl-CoA, and adenosine triphosphate (ATP), supporting energy production, redox homeostasis, and biosynthetic reactions

Epub 2011/12/03 Miyamoto K, Sato EF, Kasahara E, et al