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Conventional treatments address either the bone or the surrounding soft tissue, rarely both simultaneously
However, safety depends on several factors: injection site rotation to avoid lipodystrophy, adequate hydration (both agents can increase fluid demand), and monitoring of B vitamin status since semaglutide may affect nutrient absorption slightly during rapid weight loss phases
10.1038/nrc.2017.86 72
The mechanical load on joints compounds the inflammatory damage, and most treatments manage symptoms rather than addressing the underlying drivers
Die genaue Wirkungsweise beim Menschen ist ungeklrt
