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However, this adaptive response further imposes mitochondrial stress and elevates reactive oxygen species production (Qi et al., 2021a)

Gently swirl do not shake vigorously: Vigorous shaking can denature the peptide

It can increase susceptibility to catecholamines, like corticosteroids

Azad, F

Therefore, the overall effect of GRK2 on blood pressure is difficult to predict (vide infra)
