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The primary concern raised by the Norwegian IRB was that this RCT was violating the principle of clinical equipoise

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Furthermore, studies of IGF-2 gene in transitional cell carcinoma of the bladder and MGMT gene in gastric cancer showed that patients with CT or TT MTHFR genotypes had reduced methylation of IGF-2 or MGMT compared those with CC genotype 36,37

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Protocol adjustments should follow systematic observation rather than impulsive changes

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As with any supplement or research compound, individual responses vary significantly

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