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to open the tight junctions, thus increasing the transport of MNPs into the brain with higher specificity as compared to using EMF targeting alone, suggesting that a dual magnetic targeting-induced transport of MNPs across the BBB is an effective measure for delivery of therapeutics

Ive had minimal side effects (slight nausea and sleepiness day of and day after an injection)

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Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression

The therapeutic regimen can be revised later when symptoms improve or when patients need to receive vitamin B12 for a longer duration