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Chem Rev 121:17461803

The following is a sample of the questions most commonly asked: It became clear that the initial financial model was not adequate for answering these questions

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A notable example is the development of chemically defined, animal serum-free 3D primary human hepatocyte spheroid cultures, which eliminate fetal bovine serum, a variable, poorly characterized animal product, and demonstrate comparable viability and cytochrome P450 function, thus improving reproducibility and ethical compliance in long-term studies ( Finally, an important future direction for our work is the inclusion of serum samples from diverse ethnic and vulnerable populations, as large registry and cohort studies have shown that DILI severity can differ across populations, presumably because of individual-specific predispositions, environmental factors, cultural lifestyle, and drug-use patterns

If the serum is still liquid on your skin, wait longer