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Some flavonoids also exert anti-inflammatory effects by blocking the NLRP3 inflammasome, inhibiting proinflammatory cytokine production, and downregulating chemokines (142144)
[DOI] [PMC free article] [PubMed] [Google Scholar] 201.Chen L.-T., Weiss L

The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinsons disease

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Additionally, -Ketoglutarate(-KG) inhibited ferroptosis, significantly reducing matrix degradation and apoptosis in chondrocytes via the ETV4/SLC7A11/GPX4 signaling pathway, showing future clinical application prospects (He R