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This approach tends to be the most efficient way to deliver the medication and may require placement at two levels or on both sides (bilateral)

The notion that oxidative damage likely influences konzo susceptibility has been long theorized since this disease is associated with the consumption of cyanogenic compounds that are well known to increase radicals either through direct inhibition of mitochondrial respiration or through toxicity of the downstream metabolites of cyanide 12,18

Histopathological analysis based on Picrosirius red staining revealed a significant reduction in collagen accumulation (Fig

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