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Additional analyses using IPD and aggregate data Overall, additional analyses using both IPD and aggregate data were in agreement with the findings of the main analysis (online supplemental appendix 16)

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neoformans Regarding the virulence factors, the gpp2 strains were unable to produce urease (Figure 3A), phospholipase (Figure 3B) and melanin (Figure 3C) compared to wild type and the reconstituted strain