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FIGURE 2 Mechanical stress induced by increased IOP in glaucoma results in increased EGF receptor expression following astrocyte activation, as well as increased levels of TNF-, matrix metalloproteinases (MMPs), endothelins, and nitric oxide synthase 2 (NOS-2), ultimately leading to a neurodegenerative response (Liddelow et al., 2017

doi: 10.1177/000348941212100702

Its poor solubility, however, necessitates the development of advanced drug delivery systems, such as liposomes and nanoparticles, which enhance its therapeutic potential across various cancer types

(2022, April 5)

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