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Description
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Glutathione plays a central role in the bodys natural detox process
The model is then combined with a comprehensive glutathione metabolism model, facilitating the simulation of quinone redox cycling, and adduct-induced GSH depletion
Mechanistic studies reveal that 5-Amino-1MQ treatment decreases adipocyte size by over 30% and reduces adipocyte volume by more than 40% compared to untreated obese controls
doi: 10.1530/EC-17-0130
