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Nat Genet 46(4):357363

Challenges, considerations, and principles to guide trials of combination therapies for chronic hepatitis B virus

Dysfunction of adipocytes and chronic inflammation Studies show hypertrophic and hypoxic adipocytes in obese rats cause mitochondrial dysfunction and ROS production, while reduced antioxidant enzyme activity exacerbates OS [72]

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These are unstable molecules that can cause oxidative stress, a type of cellular "rusting" that occurs as we age or face environmental toxins