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After 6 days of senescence induction, electrophilic compounds were added at different concentrations, diluted in DMEM with 0.5% FBS

the only type of organisms that have the enzymes required for the synthesis of methylcobalamin are bacteria and archaea

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Farley and co-workers showed in the cell-free system that the catalytic efficiency of CYP4F2 for the hydroxylation of phylloquinone is higher than that of -TOH, while the co-incubation of both compounds did not influence the metabolism of phylloquinone [122]