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In accordance, quantification of immunostains for Ki67, CD31, Vimentin and SMA were also found decreased in B16-F10-challenged CreERT2 mice with respect to Igf1r fl/fl (Supplementary Fig

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Consistently, HIF1A also promotes GSH synthesis through transcriptional activation of GCLM and SLC7A11 , and pharmacological inhibition of SLC7A11 with erastin or sorafenib exacerbates cuproptosis 177,178