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In the Xenopus oocyte expression system, it is possible to observe an acute desensitization of DOR on potassium channels (Kir3) elicited by DPDPE without significant internalization measured by surface biotinylation (Celver et al., 2007)

Dtsch Z Gesamte Gerichtl Med 49, 1959

Before considering peptide therapy, patients undergo a detailed medical evaluation, including review of medical history, current medications, and appropriate laboratory testing

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The development of RNAi drugs and small molecule inhibitors targeting NNMT is facing several challenges