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Neurologia 2022;37:575-85
20 Ubiquitin harbors eight sites available for ubiquitination, including seven internal lysine (Lys, K) residues (K6, K11, K27, K29, K33, K48, and K63) and the -amino group of the N-terminal methionine (M1), which contribute to the formation of distinct homotypic polyubiquitin chains and their unique topologies