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While current clinical and basic evidence strongly supports ferroptosis as a key contributing mechanism in periodontitis progression, the extent of its role relative to classical pathogenic factors such as dysbiosis and immune dysregulation, as well as its causal temporality in the natural history of the disease, remains unclear

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This aligns with the concept of targeting multiple pathways, such as oxidative injury and apoptosis, which are implicated in drug-induced hearing loss and tinnitus

New copay caps and drug negotiations may shift costs to manufacturers and insurerswho could limit access to higher-cost therapies

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